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Submitted: 09 July 2019 Modified: 09 July 2019
HERDIN Record #: 103096-19070911020594

POWDERED MUCILAGE OF SALUYOT (Corchorus olitorius Linne, FAMILY MALVACEAE) LEAVES AS AN ALTERNATIVE PHARMACEUTICAL TABLET BINDER.

Rufo S. Calixtro,
Lezeil J. Lardizabal,
Froilan Aaron S. Faraon,
Michaela P. Diacajo

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The study was conducted to determine if the isolated powdered mucilage of saluyot (Corchorus olitorius L.) leaves can be  used as an alternative pharmaceutical tablet binder. Mucilage from the leaves of C. olitorius was extracted by digestion process. The extracted mucilage was subjected to various physicochemical tests for its suitability as an excipient in the formulation of tablet dosage form. Six percent saluyot C.olitorius leaf mucilage was used for the formulation of paracetamol tablets which were evaluated using the standard parameters such as weight variation, diameter, thickness, hardness, friability and disintegration time. Comparison was made with the formulated tablets containing the standards synthetic polyvinylpyrrolidone  (PVP) as binder. The yield of mucilage was 1.55%. The powdered leaf mucilage was light green fine amorphous, slightly soluble in water, insoluble in organic solvents and has a pH= 6.0. It exhibited good flow properties (angle of repose 33 35"), the Carr's index of 16.46, a Haussner ratio of 1.195 and swelling index of 4.0g. The formulated paracetamol tablets prepared using the mucilage has good appearance. Standard tests conducted with the tablet formulations were within the acceptable limits for weight variation, diameter, thickness, hardness, friability and disintegration time. When compared with tablets using PVP as binder, the formulated tablets with the mucilage showed no significant difference (p<0.05). The mucilage can be used as an alternative to synthetic pharmaceutical excipient to formulate solid dosage forms. Further studies can be done to conduct stability testing on the formulated tablets to determine the effect of storage on tablet's hardness, friability, disintegration and in-vitro drug release.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
UPH-Dr. Jose G. Tamayo Medical University/Medical Center
Frequency
Annual
Publication Date
July- 2018
Volume
9
Issue
1
Page(s)
22-31
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