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Submitted: 12 April 2019 Modified: 12 April 2019
HERDIN Record #: 100731-1904121408333

Clinical profile and outcome of patients with deep venous thrombosis and pulmonary embolism at Philippine Heart Center from January to December 2010.

Jennifer Ann L. Cantre,
Rosella S. Arellano

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Venous thromboembolism is comprised of pulmonary embolism and deep venous thrombosis.Although it may manifest with a variety of symptoms a significant number of patients diagnosed to have venous thromboembolism may be asymptomatic. The occurrence of venous thromboembolism results in significant morbidity and mortality such that it ranks 3rd among the "giant killers" next to stroke and myocardial infarction. It is, therefore, important to diagnose immediately and institute proper treatment. This paper is a retrospective observational study of patients admitted at PHC from January 2010-December 2010 to present the clinical profile of admitted patients with venous thromboembolism, their findings on various laboratory exams and ancillary procedures and the method of treatment and their eventual outcome. A total of 45 patients were analyzed at the end of the study.There was female predominance with a mean age of 58. They have varying presentation but the most common is swelling, dyspnea and pain/heaviness. Pulmonary embolism was made in 61.3% of patients while deep venous thrombosis was seen in 71% of patients. The most common comorbid condition seen in patients with venous thromboembolism is hypertension (46.5%), followed by diabetes (28.6%) and pulmonary disease (23.3%). Physical examination findings showed patients to be alert (93.3%), with normal blood pressure (72.7%), normal heart rate (86.7%) and regular cardiac rhythm (80.6%), with 13.3% manifesting with respiratory failure while 62.2% were noted to have edema. Work-up done on these patients included chest xray, 12 lead electrocardiogram, arterial blood gas, D-dimer determination, venous duplex scan, lung perfusion scan, Chest CT scan, and 2D echocardiogram. Medical management included anticoagulation (90.9%) using heparin (35.9%) and warfarin(65.1%) with either low molecular weight heparin or fondaparinux as a substitute. ASA and Clopidogrel were also given in some of the patients.The use of compression stockings (37.2%), the insertion of an Inferior Vena Cava (IVC) Filter (8.8%), and mechanical ventilator support (15.5%) were also some treatment modalities used. No record of thrombolysis was done. Among those patients diagnosed to have Venous Thromboembolism, 76.7% improved with management. There was a 5.4% occurrence of bleeding. 28.2% of patients afflicted with Venous thromboembolism resulted in mortality.

Publication Type
Research Report
Date
January 1-December 31, 2012
LocationLocation CodeAvailable FormatAvailability
Philippine Heart Center Medical Library PHC.IR.009.12 Abstract Print Format