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Submitted: 13 December 2017 Modified: 13 December 2017
HERDIN Record #: NCR-PHC-17121311471940

Correlation of maximal oxygen uptake (VO2 max) and BODE Index in chronic obstructive pulmonary disease patients.

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Background: CPET evaluates of both submaximal and peak exercise response, which is relevant for clinical decision-making. VO2 max; an important parameter of CPET, has been considered to reflect the severity of the disease which can predict exercise performance and exercise induced hypoxaemia in COPD patients. Another means of assessing the severity and predicting mortality of COPD is the BODE index which can predict mortality from any cause as well as respiratory causes. In this context the study intends to determine the correlation of VO2 max with BODE Index in chronic obstructive pulmonary disease patients.


 Methods: This is a cross sectional analytical study among patients enrolled and referred for pulmonary rehabilitation in Philippine Heart Center aged 40 years old and above, diagnosed with stable COPD. BODE index of patients were collected. Patients on treadmill using COPD protocol performed a symptom-limited exercise testing via CPET machine. The reason for terminating the test, VO2 max and OUES were recorded. The correlation of VO2 max with BODE index and FEV1 were analyzed and relationship of OUES with chronic obstructive pulmonary disease patients were determined.


Results: A total of 18 COPD patients were included in the study. Majority of patients showed a moderate to severe airflow obstruction in their pulmonary function. The cardio pulmonary exercise result in this study showed that a VO2 max decreased with increasing BODE index and GOLD stage. This study also showed that OUES showed a negative correlation with the BODE index.


Conclusion: It was demonstrated in this study that the maximum oxygen uptake or maximal exercise capacity utilizing CPET machine was declining in patients with advancing COPD, and this parameter can potentially identify patients benefitting from physical training training particularly pulmonary rehabilitation.


 

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