Background. Elevated serum uric acid levels were observed in clinical conditions associated with hypoxia such as heart failur, primary pulmonary hypertension and congenital heart heart disease with no report among COPD patients. Thus, this study was done to determine correlation of serum uric acid levels with hypoxemia and severity in COPD patients.
Methods. Included are 110 diagnosed COPD patients based on spirometry, grouped into stable COPD, and in acute exacerbation. Simultaneous blood extractions for serum uric acid and ABG's were determined with the patient is a steady state and in upright position. Independent t-test was employed to determine the association between serum uric acid levels with blood gas variables, age and sex. The correlation between serum uric acid levels with COPD was explored using ANOVA.
Results. A high significant correlation was noted between hypoxemia and serum uric acid levels in both stable COPD and those in exacerbations (p 05) were noted. A direct relationship was noted between COPD severity and serum uric acid levels among stable COPD patients (p>0.001), i.e., the higher the severity of COPD, the higher the serum uric acid levels. However the same relationships was not seen among COPD patients in acute exacerbation ( 0.070).
Conclusion. There is a strong correlation between hypoxemia and the severity of COPith serum uric acid level among stable COPD patients. Thus, elevated serum uric acid levels may serve as a noninvasive indicator for the severity of COPD and hypoxemia in non-exacerbating COPD patients.