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Submitted: 19 May 2016 Modified: 19 May 2016
HERDIN Record #: NCR-PHC-16051817291490

Diastolic Dysfunction as Predictor for Post-Operative Atrial Fibrillation (POAF) In Coronary Artery Bypass Graft (CABG) Patients.

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Background: Post-operative atrial fibrillation (POAF) is a major cause of morbidity and mortality. It is associated with increased risk of stroke and death and constitutes substantial use of healthcare resources, including increased duration of hospitalization and hospital costs. No local studies so far investigating the relationship of left ventricular (LV) diastolic dysfunction and the incidence of post-operative atrial fibrillation in patients undergoing elective CABG surgery. The objective of this study was to investigate whether LV diastolic dysfunction was an important pathophysiological mechanism and predictor for the initiation of new-onset post-operative atrial fibrillation (POAF).


Methods and Results: This is a prospective cohort study involving patients undergoing elective CABG at the Philippine Heart Center from March 2014 to March 2015. Results showed that male sex (p=0.019) and hypertension (p=0.036) were significantly correlated with diastolic dysfunction.Echocardiographic findings that are correlated with diastolic dysfunction were LVEF (p=0.01), LVEDD (p=0.001), LA size (p=<0.001) and LAVl (p=0.00l). We found out that there washigh statistical correlation between the severity of diastolic dysfunction and the development of PAOF in patients undergoing elective CABG (p=<0.00l), with odds ratio of 4.97 (95% Cl: 2.02-11.91, p=<0.001).


Conclusion: These results suggest that, LV diastolic dysfunction is a powerful and independent predictor for the initiation and progression of POAF. Its evaluation may be useful in risk stratification and in the initiation of pre-operative treatment for POAF in patients undergoing elective cardiac surgery.

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Research Project
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Philippine Heart Center Medical Library PHC.R.021.13 Fulltext Print Format