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Submitted: 12 November 2014 Modified: 08 October 2018
HERDIN Record #: PCHRD14111206481233

Baseline high-density lipoprotein cholesterol as a predictor of major adverse cardiac events after elective percutaneous coronary stenting among Filipinos

Jun Maximo F. Lasco II,
Gibert C. Vilela

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BACKGROUND: Low high density lipoprotein (HDL), a common problem among Filipinos, is associated with cardiovascular disease. The association between HDL  and outcomes of coronary stenting particularly among Filipinos has not been evaluated.


METHODOLOGY: Adult patients who underwent elective coronary stenting were included in the study. Baseline demographic, clinical and angiographic variables were determined. Baseline lipid profile was taken. Association between baseline HDL stratified into low (,40mg/dL in men, 45mg/dL in women) and high levels (≥40 mg/ dL in men and ≥45 mg/ dL in women) with MACE at 1 month and 1 year was prospectively determined.


RESULT: A total of 126 patients, 55 with high HDL and 71 with low HDL, were included in the study. The mean levels of HDL of the two groups were 50 mg/dL and 34 mg/ dL, respectively. The high HDL group was generally older, had lower triglyceride levels, had fewer smokers, and had more left anterior descending artery involvement. Both groups had similar event-rates during the first 30 days post-stenting. However, the composite of MACE during the 31st day to 1 year was significantly higher in the low HDL group (5(9.1%) vs 13(18.3%); p=0.007) even after adjusting for baseline characteristics. This result was largely driven by acute myocardial infarction and stroke (9.8% vs 1.8 and 8.5 vs 5.5% for low and high HDL group, respectively).


CONCLUSION: Low baseline HDL (<40mg/dL in men, <45 mg/dL in women) is an independent predictor of MACE at one year among Filipinos who underwent coronary stenting.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Cardiology
Frequency
Semi-Annual
Publication Date
January-June 2013
Volume
41
Issue
1
Page(s)
30-34

Objectives

OBJECTIVE: To determine the association of baseline HDL levels to major adverse cardiac events (MACE) at 1 month and 1 year after percutaneous coronary stenting among Filipinos.


 

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 43 Fulltext Print Format (Request Document)
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Philippine Heart Center Medical Library PHC.R.032.10 Fulltext pdf (Download)