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Submitted: 10 July 2012 Modified: 28 August 2012
HERDIN Record #: PCHRD12071015180133

Diagnostic value of antithyroglobulin antibodies in the detection of recurrent differentiated thyroid carcinoma: A meta-analysis.

Angelin F. Apostol,
Jerry M. Obaldo

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The aim of this study is to determine the diagnostic accuracy of antithyroglobulin antibodies in predicting recurrent differentiated thyroid carcinoma. We searched PubMed (1990-2010) and Google Scholar (1990-2010). Citation searches, manual searches and screening of references of f included studies were done. Diagnostic studies that utilized antithyroglobulin antibodies as a predictor of recurrent differentiated thyroid carcinoma. The authors searched citations that correlated with the criteria using a data collection form generated in Review Manager 5 (REVMAN 5). The methodological quality was then assessed using Quality Assessment of Studies of Diagnostic Accuracy (QUADAS). Hierarchical summary receiver operating characteristic (HSROC) mete-analytical tool was used to estimate summary receiver operating characteristic (ROC) curves. Eight studies with 2116 participants with 182 patients with recurrent differentiated thyroid carcinoma were included. Pooled sensitivity and specifically were 63% and 79% respectively. SROC shows an overall are under the curve (AUC) of 0.712. Antithyroglobulin antibody has ability to predict recurrent differentiated thyroid carcinoma.

Publication Type
Journal
Publication Sub Type
Metaanalysis
Title
The Philippine Journal of Nuclear Medicine
Frequency
Semi-Annual
Publication Date
July-December 2012
Volume
7
Issue
2
Page(s)
17-23
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 21 Fulltext Print Format (Request Document)