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Submitted: 26 August 2011 Modified: 13 April 2012
HERDIN Record #: PCHRD08261101083714

Thyroid function in thyroid carcinoma: A 5-year retrospective Analysis .

Suzette S. Quiaoit

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Background: Several studies investigated the behavior of thyroid stimulating hormone (TSH) among patients with documented thyroid carcinoma . Elevations of TSH are commonly seen and only fraction of thyroid carcinomas present with low TSH levels

Objectives:To describe the thyroid function in thyroid carcinomas.

Setting : St. Lukes's Medical Center , Quezon City Philippines ( Tertiary Institution)

Design: Retrospective Study

Results: A total of 400 patients were analyzed . There was a slight female predominance , with a mean age of 44 years ( range 14-86) , residing mostly in Metro Manila , with a family history of MEN-II in 14 % and medullary carcinoma in 2% . Papillary carcinoma and forllicular CA were the most common histologic types . Most underwent total thyroidectomy with necl lymph node dissection in 63% Mean TSH values did not statiscally differ across the histologic types of cancer (p=.91) . Majority (78%) had normal TSH (0.4-4.65 mIU/L) despite tumor size (p=0.39) and nodal involvement (p=.035) . Values of TSH did not statiscally vary with metastasis and overall staging (p=.24, p=.63 respectively).

Conclusion: Normal TSH levels were commonly seen in this sample of thyroid carcinomas . TSH determination in thyroid carcinoma guide clinicians regarding suppressive thyroid hormone therapy

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Internal Medicine
Frequency
Bimonthly
Publication Date
March-April 2009
Volume
47
Issue
2
Page(s)
65-70

Objectives

To describe the thyroid function in thyroid carcinomas.

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No.48 Fulltext Print Format (Request Document)