A single-blind randomized study was done comparing the sterilizing activities of glutaraldehyde and saponated cresol at one hour soaking, 5 hours and 10 hours. The subjects were 120 gauge 23 hypodermic needles contaminated with E. coli and S. aureus.
Results showed that cresol is comparable to glutaradehyde in decreasing induced bacterial growth. One hour of soaking in sterilizing solutions is probably sufficient, as compared to 5 and 10 hours. Multifactoral ANOVA values of F=1.678 for S. aureus and F=0.561 for E. coli at p 0.05 were not statistically significant.
Seventy percent isopropanol may have some synergistic effect on glutaraldehyde. This study even shows that isopropanol can be a good sterilizing agent.
General Objectives: To compare cresol with glutaraldehyde as a disinfecting and sterilizing solution.Specific Objectives:1. To determine if cresol is comparable to glutaraldehyde as a disinfecting and sterilizing solution in terms of decreasing the bacterial count.2. To determine the ideal soaking time of cresol.3. To determine if isopropanol has a synergetic effect on the action of glutaraldehyde.4. To determine if ten hours soaking time with glutaraldehyde is really necessary.